Neuronal activity is the result of the orchestrated actions of multitudes of synapses, acting and evolving not as individuals, but as populations. These are shaped by essential processes of learning and homeostasis. Meanwhile, theoretical work shows that distributions of synaptic strengths...

This repository contains high-resolution molecular maps and proteomic data characterizing the diversity of billions of individual synapses across the human brain, as pioneered by the Grant Lab at the University of Edinburgh. The dataset captures the "synaptome architecture," illustrating how the...

The DMBM dataset provides high-resolution, whole-brain synaptic microscopy image covering 118 subregions of significant interest in neuroscience. The images consist of scans targeting the postsynaptic density proteins SAP102 and PSD95.

Synapse pathology is a feature of most brain diseases and there is a pressing need to monitor the onset and progression of this pathology using brain imaging in living patients. A major step toward this goal has been the development of small-molecule radiotracers that bind to synaptic vesicle...